Vivaldis Pimoben (Pimobendan & Benazepril Hydrochloride) Dual-Action Cardiac Tablets for Dogs

Select Variant: 1

Description

Prolong survival, enhance exercise stamina, and relieve clinical signs of canine heart disease with Vivaldis Pimoben Tablets, available online at PetMitra. Congestive Heart Failure (CHF)—most commonly driven by degenerative Myxomatous Mitral Valve Disease (MMVD) in small-to-medium dogs or Dilated Cardiomyopathy (DCM) in large breeds—triggers a progressive cycle of poor cardiac output, dangerous compensatory neurohormonal activation, cardiac remodeling, and congestive pulmonary edema (fluid in the lungs).Managing heart failure historically required administering separate tablets of an inodilator and an ACE inhibitor multiple times daily. Vivaldis Pimoben combines both frontline cardiovascular drugs into a single scored tablet:Positive Inotropy & Balanced Vasodilation (Pimobendan): Acts as a calcium-sensitizing inodilator. It sensitizes myocardial contractile proteins (troponin C) to intracellular calcium, increasing cardiac contractile force ($+dP/dt$) without raising myocardial oxygen consumption. Concurrently, it inhibits phosphodiesterase III (PDE-III), causing peripheral and coronary vasodilation to reduce cardiac afterload.Neurohormonal Renin-Angiotensin System Blockade (Benazepril HCl): A prodrug converted in the liver to benazeprilat, a potent inhibitor of Angiotensin-Converting Enzyme (ACE). By blocking the conversion of Angiotensin I to Angiotensin II, it prevents systemic vasoconstriction, lowers vascular resistance, halts aldosterone secretion, and curbs excessive sodium and water retention. This dual action blunts adverse cardiac hypertrophy and protects renal hemodynamics.Synergistic Hemodynamic Unloading: Combining the forward-pumping power of Pimobendan with the systemic pressure-unloading action of Benazepril reduces left atrial pressure, eases nocturnal coughing and breathlessness, slows disease progression, and improves quality of life.